Polyclonal Antibody to p21Cip1 (Phospho-Thr145)
May be the important intermediate by which p53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression.
Product Specifications
Product Name Alternative
CAP20|| CDK-interacting protein 1|| CDKN1|| CDKN1A|| CDN1A
Gene Name
CDKN1A
Gene ID
1026
UniProt
P38936
Host
Rabbit
Reactivity
Human
Immunogen
Peptide sequence around phosphorylation site of threonine 145 (R-Q-T (p) -S-M) derived from Human p21Cip1.
Target Antigen
P21Cip1 (Phospho-Thr145)
Clonality
Polyclonal
Applications
IHC
Format
Purified
Components
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Predicted MW: 21kd, Immunohistochemistry: 1:50~1:100
Isotype
Rabbit IgG
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