Anti-PMEL antibody (DMC420) ; IgG1 Chimeric mAb

Description :Anti-PMEL antibody (DMC420) ; IgG1 Chimeric mAbThis gene encodes a melanocyte-specific type I transmembrane glycoprotein. The encoded protein is enriched in melanosomes; which are the melanin-producing organelles in melanocytes; and plays an essential role in the structural organization of premelanosomes. This protein is involved in generating internal matrix fibers that define the transition from Stage I to Stage II melanosomes. This protein undergoes a complex pattern of prosttranslational processing and modification that is essential to the proper functioning of the protein. A secreted form of this protein that is released by proteolytic ectodomain shedding may be used as a melanoma-specific serum marker. Alternate splicing results in multiple transcript variants.

Product Specifications

Product Name Alternative

D12S53E; gp100; ME20; ME20-M; ME20M; P1; P100; PMEL17; SI; SIL; SILV

UniProt

P40967

Host

Rabbit

Reactivity

Human

Target Antigen

PMEL

Clonality

Monoclonal

Clone

DMC420

Applications

FACS

Purification

Purified from cell culture supernatant by affinity chromatography

Components

Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.

Storage Conditions

Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing) . Lyophilized proteins are shipped at ambient temperature.