PROTAC FLT-3 degrader 1
Product Specifications
UNSPSC Description
PROTAC FLT-3 degrader 1 is an effective and selective FLT-3 PROTAC degrader with an IC50 of 0.6 nM. PROTAC FLT-3 degrader 1 inhibits both FLT-3 and FLT-3 ITD mutants. PROTAC FLT-3 degrader 1 has the activity of anti-proliferation and induction of apoptosis, which can be used in the study of tumor. (Pink: FLT3 ligand (HY-168702); Black: Linker (HY-124380); Blue: VHL ligand (HY-125845))[1].
Target Antigen
Apoptosis; ERK; FLT3; MEK; PROTACs; STAT
Type
Reference compound
Related Pathways
Apoptosis;JAK/STAT Signaling;MAPK/ERK Pathway;PROTAC;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-flt-3-degrader-1.html
Purity
99.74
Solubility
DMSO : 150 mg/mL (ultrasonic)
Smiles
O=C(N[C@@H](C(C)(C)C)C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)CCOCCOCCOC4=CC5=C(N6C(S5)=NC(C7=CC=C(NC(NC8=NOC(C(C)(C)C)=C8)=O)C=C7)=C6)C=C4
Molecular Weight
1020.23
References & Citations
[1]Burslem GM, et al. Enhancing Antiproliferative Activity and Selectivity of a FLT-3 Inhibitor by Proteolysis Targeting Chimera Conversion. J Am Chem Soc. 2018 Dec 5;140(48):16428-16432.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-114323/PROTAC-FLT-3-degrader-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-114323/PROTAC-FLT-3-degrader-1-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2230826-81-8
Available Sizes
Curated Selection
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