PROTAC FLT-3 degrader 1

PROTAC FLT-3 degrader 1 is an effective and selective FLT-3 PROTAC degrader with an IC50 of 0.6 nM. PROTAC FLT-3 degrader 1 inhibits both FLT-3 and FLT-3 ITD mutants. PROTAC FLT-3 degrader 1 has the activity of anti-proliferation and induction of apoptosis, which can be used in the study of tumor. (Pink: FLT3 ligand (HY-168702) ; Black: Linker (HY-124380) ; Blue: VHL ligand (HY-125845) ) [1].

Product Specifications

CAS Number

[2230826-81-8]

UNSPSC

12352005

Target

Apoptosis; ERK; FLT3; MEK; PROTACs; STAT

Type

Reference compound

Related Pathways

Apoptosis; JAK/STAT Signaling; MAPK/ERK Pathway; PROTAC; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/protac-flt-3-degrader-1.html

Purity

99.74

Solubility

DMSO : 150 mg/mL (ultrasonic)

Smiles

O=C(N[C@@H](C(C)(C)C)C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)CCOCCOCCOC4=CC5=C(N6C(S5)=NC(C7=CC=C(NC(NC8=NOC(C(C)(C)C)=C8)=O)C=C7)=C6)C=C4

Molecular Formula

C52H61N9O9S2

Molecular Weight

1020.23

References & Citations

[1]Burslem GM, et al. Enhancing Antiproliferative Activity and Selectivity of a FLT-3 Inhibitor by Proteolysis Targeting Chimera Conversion. J Am Chem Soc. 2018 Dec 5;140 (48) :16428-16432.