(-) -Epicatechin-13C3

(-) -Epicatechin-13C3 ((-) -Epicatechol-13C3) is 13C labeled (-) -Epicatechin. (-) -Epicatechin inhibits cyclooxygenase-1 (COX-1) with an IC50 of 3.2 μM. (-) -Epicatechin inhibits the IL-1β-induced expression of iNOS by blocking the nuclear localization of the p65 subunit of NF-κB.

Product Specifications

Product Name Alternative

(-) -Epicatechol-13C3; Epicatechin-13C3; epi-Catechin-13C3

UNSPSC

12352005

Target

COX; Endogenous Metabolite; Ferroptosis; Isotope-Labeled Compounds

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; Others

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Smiles

OC1=[13C]2[13CH2][C@@H](O)[C@@H](C3=CC=C(O)C(O)=C3)O[13C]2=CC(O)=C1

Molecular Formula

C12 13C3H14O6

Molecular Weight

293.25

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Waffo-Téguo P, et al. Potential cancer-chemopreventive activities of wine stilbenoids and flavans extracted from grape (Vitis vinifera) cell cultures. Nutr Cancer. 2001;40 (2) :173-9.|[3]Shay J, et al. Molecular Mechanisms and Therapeutic Effects of (-) -Epicatechin and Other Polyphenols in Cancer, Inflammation, Diabetes, and Neurodegeneration. Oxid Med Cell Longev. 2015;2015:181260.|[4]Nogueira L, et al. (-) -Epicatechin enhances fatigue resistance and oxidative capacity in mouse muscle. J Physiol. 2011 Sep 15;589 (Pt 18) :4615-31.