MRP1-IN-2
MRP1-IN-2 (Compound 21) is a selective MRP1 inhibitor with a relatively weak inhibitory effect on P-gp. MRP1-IN-2 exhibits a strong accumulation effect of calcein, with its EC50 value being 177 nM. MRP1-IN-2 enhances the activity of Doxorubicin (HY-15142A) on drug-resistant cells. MRP1-IN-2 can be used for the study of multidrug-resistant cancers[1].
Product Specifications
UNSPSC
12352005
Target
P-glycoprotein
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Cancer
Smiles
NC1=NC(N2CC3(CCOCC3)C2)=C(C(C)CC)C(C4=C(F)C(F)=CC=C4)=N1
Molecular Formula
C21H26F2N4O
Molecular Weight
388.45
References & Citations
[1]Čičak M, et al. The 2-aminopyrimidine ring as a new scaffold for potent MRP1 inhibitors. Eur J Med Chem. 2026 Jan 15;302 (Pt 3) :118364.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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