JP-163-16
JP-163-16 is a RelA/p65 PROTAC degrader. JP-163-16 selectively reduces the expression of RelA/p65 in a proteasome-dependent manner in cells. JP-163-16 can induce cell apoptosis by inhibiting the NF-κB signaling pathway. JP-163-16 can be used for research on RelA/p65-dependent tumours, such as chronic lymphocytic leukaemia (CLL) . (Pink: RelA/p65 Ligand (HY-174865) ; Blue: CRBN Ligand (HY-A0003) ; Black: Linker; CRBN Ligand+Linker (HY-160241) ) [1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; NF-κB; PROTACs
Related Pathways
Apoptosis; NF-κB; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C(NC1=CC=C(NC(CCCOC2=C(OC)C=C3C(N=C[C@@](CCC4)([H])N4C3=O)=C2)=O)C=C1)CCCCCNC5=CC=CC6=C5CN(C(CC7)C(NC7=O)=O)C6=O
Molecular Formula
C42H47N7O8
Molecular Weight
777.86
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon; RelA/p65
Available Sizes
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