RIPK2/3-IN-2
RIPK2/3-IN-2 (29) is a dual RIPK2 and RIPK3 inhibitor, with IC50 values of 12 nM and 18 nM, respectively. RIPK2/3-IN-2 (29) induces necroptosis, with an EC50 of 0.16 μM[1].
Product Specifications
UNSPSC
12352005
Target
RIP kinase
Related Pathways
Apoptosis
Field of Research
Inflammation/Immunology
Purity
99.67
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
FC1=C(NC2=NC=NC3=CC(C4=CC=C(N=C4)N5CCOCC5)=CC=C32)C=CC=C1
Molecular Formula
C23H20FN5O
Molecular Weight
401.44
References & Citations
[1]Duo Ma, et al. Discovery of Potent and Balanced Dual RIPK2 and 3 Inhibitors as a New Strategy for the Treatment of Inflammatory Bowel Diseases. J Med Chem. 2025 Apr 10;68 (7) :7539-7559.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-173454/RIPK2-3-IN-2-SDS-MedChemExpress.pdf
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
RIPK2; RIPK3
Available Sizes
Curated Selection
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