2- (cyclohexylmethyl) -Plumbagin
This naphthoquinone derivative demonstrates potent, nutrient-deprivation selective cytotoxicity against PANC-1 pancreatic cancer cells (PC50 0.11 μM) by inducing apoptosis and inhibiting Akt/mTOR phosphorylation. It also significantly reduces tumor growth in MiaPaCa-2 mouse xenograft models, supporting its study in pancreatic cancer research under tumor microenvironment-mimicking conditions.
Product Specifications
Smiles
OC1=C2C (C (C (CC3CCCCC3) =CC2=O) =O) =CC=C1
Molecular Formula
C17H18O3
Molecular Weight
270.30
Storage Conditions
-20°C
Notes
For research use only.
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