Ac-LEVD-CHO (TFA)
Ac-LEVD-CHO (TFA) is an inhibitor of caspase-4. Ac-LEVD-CHO (TFA) can inhibit the expression and secretion of IL-1α expression as well as the activation of caspase-4 induced by the T. denticola periodontal pathogen surface protein Td92 in human gingival fibroblasts. Ac-LEVD-CHO (TFA) can also reduce the apoptosis due to the expression of the dominant negative adenoviral RNA-dependent protein kinase in A549 and PC3 cancer cell lines[1][2].
Product Specifications
UNSPSC
12352209
Target
Apoptosis; Caspase
Related Pathways
Apoptosis
Field of Research
Cancer
Smiles
OC(C[C@@H](C=O)NC([C@H](C(C)C)NC([C@H](CCC(O)=O)NC([C@@H](NC(C)=O)CC(C)C)=O)=O)=O)=O.FC(C(O)=O)(F)F
Molecular Formula
C24H37F3N4O11
Molecular Weight
614.57
References & Citations
[1]Jun, H. K., et al., (2018) . Caspase-4 activation by a bacterial surface protein is mediated by cathepsin G in human gingival fibroblasts. Cell death and differentiation, 25 (2), 380–391.|[2]Pataer, A., et al., (2009) . Inhibition of RNA-dependent protein kinase (PKR) leads to cancer cell death and increases chemosensitivity. Cancer biology & therapy, 8 (3), 245–252.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
orb1651932-01 20 µg
Recombinant Human 26S proteasome non-ATPase regulatory subunit 11 protein (PSMD11)
Sign In for Pricing
View Details orb1651932-02 100 µg
Recombinant Human 26S proteasome non-ATPase regulatory subunit 11 protein (PSMD11)
Sign In for Pricing
View Details orb1651932-03 1 mg
Recombinant Human 26S proteasome non-ATPase regulatory subunit 11 protein (PSMD11)
Sign In for Pricing
View Details 
orb2936358-01 20 µg
Recombinant Staurastrum punctulatum ATP synthase subunit c, chloroplastic (atpH)
Sign In for Pricing
View Details orb2936358-02 100 µg
Recombinant Staurastrum punctulatum ATP synthase subunit c, chloroplastic (atpH)
Sign In for Pricing
View Details 
abx403504-01 100 µL
Adhesion G Protein-Coupled Receptor E5 (ADGRE5) Antibody
Sign In for Pricing
View Details