Smo antagonist M25

Smo antagonist M25 is a smoothened antagonist for inhibition of the hedgehog pathway.

Product Specifications

CAS Number

[1186293-14-0]

UNSPSC

12352005

Target

Hedgehog; Smo

Related Pathways

Stem Cell/Wnt

Field of Research

Cancer

Smiles

O=C(NCC1=CC=C2N(N=CC2=C1)C3=CC=CC=C3OC)C(CCC)CCC

Molecular Formula

C23H29N3O2

Molecular Weight

379.50

References & Citations

[1]Dessole G, Branca D, Ferrigno F, Kinzel O, Muraglia E, Palumbi MC, Rowley M, Serafini S, Steinkühler C, Jones P. Discovery of N-[ (1-aryl-1H-indazol-5-yl) methyl]amides derivatives as smoothened antagonists for inhibition of the hedgehog pathway. Bioorg Med Chem Lett. 2009 Aug 1;19 (15) :4191-5. doi: 10.1016/j.bmcl.2009.05.112. Epub 2009 Jun 2. PMID: 19540115.