Afegostat
Afegostat is a pharmacological chaperone, which specifically and reversibly binds acid-β-glucosidase (GCase) in the endoplasmic reticulum (ER) with high affinity[1].
Product Specifications
CAS Number
[169105-89-9]
Product Name Alternative
D-Isofagomine; Isofagomine
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
Glycosidase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Afegostat.html
Purity
99.96
Solubility
H2O : 4.17 mg/mL (ultrasonic)
Smiles
O[C@@H]1CNC[C@H](CO)[C@H]1O
Molecular Formula
C6H13NO3
Molecular Weight
147.17
Precautions
H315, H319, H320
References & Citations
[1]Richter F, et al. A GCase chaperone improves motor function in a mouse model of synucleinopathy. Neurotherapeutics. 2014 Oct;11 (4) :840-56.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
Curated Selection
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