Afegostat
Product Specifications
UNSPSC Description
Afegostat is a pharmacological chaperone, which specifically and reversibly binds acid-β-glucosidase (GCase) in the endoplasmic reticulum (ER) with high affinity[1].
Target Antigen
Glycosidase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Afegostat.html
Solubility
H2O : 5 mg/mL (ultrasonic)
Smiles
O[C@@H]1CNC[C@H](CO)[C@H]1O
Molecular Weight
147.17
References & Citations
[1]Richter F, et al. A GCase chaperone improves motor function in a mouse model of synucleinopathy. Neurotherapeutics. 2014 Oct;11(4):840-56.
Shipping Conditions
Blue Ice
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-14829/Afegostat-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-14829/Afegostat-SDS-MedChemExpress.pdf
Clinical Information
Phase 2
CAS Number
169105-89-9
Available Sizes
Curated Selection
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