6-hydroxy Bexarotene

6-Hydroxy Bexarotene, an oxidative metabolite of bexarotene, serves as a high-affinity ligand for retinoid X receptors (RXRs), specifically binding to RXR?, RXR?, and RXR?, as well as to the retinoic acid receptor ? (RAR?) with dissociation constants (Kds) of 3.46, 4.21, 4.83, and 8.17 ?M, respectively. It demonstrates selective activation of RXR?, RXR?, and RXR? over RAR?, RAR?, and RAR? in vitro, with half-maximal effective concentrations (EC50s) of 398, 356, 420, 4,414, 2,121, and 2,043 nM, respectively.