GPR84 antagonist 2
Product Specifications
CAS Number
2244269-74-5
Target
GPCR, Others
Related Pathways
GPCR/G Protein, Endocrinology/Hormones, Others
Bioactivity
GPR84 Antagonist 2, a potent and selective GPR84 antagonist (IC 50 = 8.95 nM), demonstrates oral activity and significantly enhances potency in calcium mobilization assays. It effectively inhibits neutrophil and macrophage chemotaxis following GPR84 activation, highlighting its research potential for ulcerative colitis.
Smiles
O=P(OC1=CC2=C(SC3=C1C=CC=C3)C=CC=C2Cl)(OC4=CC5=C(SC6=C4C=CC=C6)C=CC=C5Cl)[O-].[Na+]
Molecular Formula
C28H16Cl2NaO4PS2
Molecular Weight
605.42
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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