CLM3
Product Specifications
CAS Number
1312024-59-1
Target
EGFR, Apoptosis, VEGFR, c-RET
Related Pathways
Tyrosine Kinase/Adaptors, Apoptosis, Angiogenesis, JAK/STAT signaling
Bioactivity
CLM3, a pyrazolopyrimidine derivative, functions as a multitargeted tyrosine kinase inhibitor. It exhibits antiproliferative and proapoptotic activities on endothelial and cancer cells, activities that are synergistically enhanced by SN38. The primary mechanism of action for CLM3 involves the inhibition of phosphorylation in tyrosine kinases such as VEGFR-2, EGFR, and RET, along with their associated signaling pathways.
Smiles
N([C@H](C)C1=CC=CC=C1)C2=C3C(N(CCC4=CC=CC=C4)N=C3)=NC=N2
Molecular Formula
C21H21N5
Molecular Weight
343.43
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
F6070-01-Biotin 100 µL
Francisella tularensis, LPS (Biotin) discontinued
Sign In for Pricing
View Details 
orb2611855 100 µg
Niemann Pick C2/NPC2 Rabbit Polyclonal Antibody (Cy3)
Sign In for Pricing
View Details 
orb2911869-01 20 µg
Recombinant Mycobacterium gilvum Cobalamin synthase (cobS)
Sign In for Pricing
View Details orb2911869-02 100 µg
Recombinant Mycobacterium gilvum Cobalamin synthase (cobS)
Sign In for Pricing
View Details