Biotinylated Cynomolgus Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein, His, Avitag™&Tag Free

Integrin alpha V beta 6 is a heterodimer of beta-6 associating with alpha-V. Integrin alpha-V beta-6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalisation of integrin alpha-V beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion. Also, Integrin alpha-V beta-6 acts as a receptor for coxsackievirus A9 and coxsackievirus B1 as well as herpes simplex virus-1/HHV-1. Furthermore, it binds the TGF-beta latency‑associated peptide (LAP) and activates TGF-beta 1 or TGF-beta 3 from large latent complexes. This activation requires interaction with LTBP-1 and fibronectin, and is enhanced by PAR-1.

Product Specifications

Background

Specifications

Biotinylated Cynomolgus ITGAV&ITGB6 Heterodimer Protein, His, Avitag&Tag Free, produced by co-expression of ITGAV and ITGB6, has a calculated MW of 114.8 kDa (ITGAV) & 79.9 kDa (ITGB6) . Subunit ITGAV is fused with an acidic tail at the C-terminus and followed by a polyhistidine tag and an Avi tag (Avitag™) and subunit ITGB6 contains no tag but a basic tail at the C-terminus. The protein migrates as 130-150 kDa (ITGAV) and 80-95 kDa (ITGB6) when calibrated against Star Ribbon Pre-stained Protein Marker under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.

Expression Region

Phe 31 - Pro 993 & Gly 22 - Pro 709

Target

Integrin alpha V beta 6

Conjugation

Biotin-labeled

Tag

C-10xHis & C-Avi | Native

Stability

-20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.