Z-Val-Val-Nle-diazomethylketone
Product Specifications
CAS Number
155026-49-6
Target
Cysteine Protease|||MHC
Related Pathways
Immunology/Inflammation|||Proteases/Proteasome
Bioactivity
Z-Val-Val-Nle-diazomethylketone is an inhibitor of cathepsin S (CATS) . It significantly suppresses the upregulation of IFNg-induced MHCII molecules, specifically HLA-DR and Ii-p33/35, while increasing the protein level of Ii-p10. This compound can be utilized for research into skin disorders such as psoriasis, atopic dermatitis, and actinic keratosis.
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[C@@H](NC([C@@H](NC([C@@H](NC(OCC1=CC=CC=C1)=O)C(C)C)=O)[C@@H](C)C)=O)(C(C=[N+]=[N-])=O)CCCC
Molecular Formula
C25H37N5O5
Molecular Weight
487.59
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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