IL-10
Interleukin 10 (IL-10), initially designated cytokine synthesis inhibitory factor (CSIF), was originally identified as a product of mouse T helper (Th) 2 clones that inhibited cytokine production by Th1 clones . The human ortholog of mouse IL-10 was subsequently cloned by cross-hybridization. Human and mouse IL-10 are 81% identical at the nucleotide and amino acid level. IL-10 is the prototypic member of the IL-10 cytokine family, including IL-10, IL-19, IL-20, IL-22 (IL-TIF), IL-24 and IL-26. A number of viruses, including Epstein-Barr virus (EBV) and human cytomegalovirus (HCMV), also encode viral members of the IL-10 family. Human IL-10 has cross-species actvity and is active on mouse cells. Rat and mouse IL-10 is species-specific and does not act on human cells.
Product Specifications
Synonyms
Il10; IL10X
NCBI Gene ID
25325
UniProt
P29456
Accession Number
NP_036986
Accession Number mRNA
NM_012854
Chromosomal Location
13q13
Reactivity
Rat
Cross Reactivity
Mouse, Rat
Sequence
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
The ED50 as determined by the dose-dependent inhibition of antigen-specific T cell proliferation is ≤10ng/ml.
Length
160
Form
Lyophilized
Molecular Weight
18.7 kDa
Host or Source
E. coli
Frequently Asked Questions
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