VISTA Antibody [8E11]
Product Specifications
Background
VISTA Antibody: VISTA/B7-H5/platelet receptor Gi24 is a single-pass type I membrane protein located at the cell surface. It is an immunoregulatory receptor which can inhibit T-cell response and may promote differentiation of embryonic stem cells, by inhibiting the BMP4 signaling pathway. The protein can be cleaved by MMP14, and stimulate MMP14-mediated MMP2 activation.
NCBI Gene ID
64115
Swiss Prot
Q9H7M9
Accession Number
NP_071436
Host
Mouse
Reactivity
Human
Immunogen
VISTA antibody was raised against the extracellular domain of human VISTA.
Clonality
Monoclonal
Clone
8E11
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology
Purification
VISTA Antibody is supplied as protein A purified IgG1.
Positive Control
Cat. No. 1331 - Human Lymphoma Tissue Lysate
Concentration
1 mg/mL
Buffer
VISTA Antibody is supplied in PBS containing 0.02% sodium azide and 50% glycerol.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
VISTA antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=RF16073
Fragment
IgG1
Symbol
VSIR
Positive Control 2
Cat. No. 1306 - Human Spleen Tissue
NCBI Official Name
VISTA molecule
NCBI Organism
Homo sapiens
Background Reference 01
Mayya V., et al . Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. 2009, Sci. Signal. 2:RA46-RA46.
Background Reference 02
Sakr M.A., et al., GI24 enhances tumor invasiveness by regulating cell surface membrane-type 1 matrix metalloproteinase. 2010, Cancer Sci. 101:2368-2374.
Other Product Names
VISTA Antibody: VISTA molecule, VSIR, B7-H5, B7H5, GI24, PP2135, SISP1, DD1alpha, VISTA, C10orf54, chromosome 10 open reading frame 54, PD-1H, V-set immunoregulatory receptor, V-Type Immunoglobulin Domain-Containing Suppressor Of T-Cell Activation, Chromosome 10 Open Reading Frame 54
Tested Applications
ELISA, IHC-P, ICC, IF, Flow
Protein ID
64115
Physical Properties
Liquid
Available Sizes
Curated Selection
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