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VISTA Antibody [8E11]

Product Specifications

Background

VISTA Antibody: VISTA/B7-H5/platelet receptor Gi24 is a single-pass type I membrane protein located at the cell surface. It is an immunoregulatory receptor which can inhibit T-cell response and may promote differentiation of embryonic stem cells, by inhibiting the BMP4 signaling pathway. The protein can be cleaved by MMP14, and stimulate MMP14-mediated MMP2 activation.

NCBI Gene ID

64115

Swiss Prot

Q9H7M9

Accession Number

NP_071436

Host

Mouse

Reactivity

Human

Immunogen

VISTA antibody was raised against the extracellular domain of human VISTA.

Clonality

Monoclonal

Clone

8E11

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Immunology

Purification

VISTA Antibody is supplied as protein A purified IgG1.

Positive Control

Cat. No. 1331 - Human Lymphoma Tissue Lysate

Concentration

1 mg/mL

Buffer

VISTA Antibody is supplied in PBS containing 0.02% sodium azide and 50% glycerol.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

VISTA antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Fragment

IgG1

Symbol

VSIR

Positive Control 2

Cat. No. 1306 - Human Spleen Tissue

NCBI Official Name

VISTA molecule

NCBI Organism

Homo sapiens

Background Reference 01

Mayya V., et al . Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. 2009, Sci. Signal. 2:RA46-RA46.

Background Reference 02

Sakr M.A., et al., GI24 enhances tumor invasiveness by regulating cell surface membrane-type 1 matrix metalloproteinase. 2010, Cancer Sci. 101:2368-2374.

Other Product Names

VISTA Antibody: VISTA molecule, VSIR, B7-H5, B7H5, GI24, PP2135, SISP1, DD1alpha, VISTA, C10orf54, chromosome 10 open reading frame 54, PD-1H, V-set immunoregulatory receptor, V-Type Immunoglobulin Domain-Containing Suppressor Of T-Cell Activation, Chromosome 10 Open Reading Frame 54

Tested Applications

ELISA, IHC-P, ICC, IF, Flow

Protein ID

64115

Physical Properties

Liquid

Available Sizes

Frequently Asked Questions

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