LC3-mHTT-IN-AN1
Product Specifications
UNSPSC Description
LC3-mHTT-IN-AN1 (Compound AN1) is a mHTT-LC3 linker compound, which interacts with both mutant huntingtin protein (mHTT) and LC3B but not with wtHTT or irrelevant control proteins. LC3-mHTT-IN-AN1 reduces the levels of mHTT in an allele-selective manner in cultured Huntington disease (HD) mouse neurons[1].
Target Antigen
Atg8/LC3; ATTECs; Autophagy
Type
Reference compound
Related Pathways
Autophagy;PROTAC
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/lc3-mhtt-in-1.html
Purity
98.99
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
BrC1=CC=C(C/2=C1)NC(C2=C/C3=CC(Br)=C(C(O)=C3)O)=O
Molecular Weight
411.04
References & Citations
[1]Li Z, et al. Allele-selective lowering of mutant HTT protein by HTT-LC3 linker compounds. Nature. 2019 Nov;575(7781):203-209.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-130258/LC3-mHTT-IN-AN1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-130258/LC3-mHTT-IN-AN1-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
486443-73-6
Available Sizes
Curated Selection
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