LC3-mHTT-IN-AN1
LC3-mHTT-IN-AN1 (Compound AN1) is a mHTT-LC3 linker compound, which interacts with both mutant huntingtin protein (mHTT) and LC3B but not with wtHTT or irrelevant control proteins. LC3-mHTT-IN-AN1 reduces the levels of mHTT in an allele-selective manner in cultured Huntington disease (HD) mouse neurons[1].
Product Specifications
CAS Number
[486443-73-6]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Atg8/LC3; Autophagy
Type
Reference compound
Related Pathways
Autophagy
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/lc3-mhtt-in-1.html
Purity
98.86
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
BrC1=CC=C(C/2=C1)NC(C2=C/C3=CC(Br)=C(C(O)=C3)O)=O
Molecular Formula
C15H9Br2NO3
Molecular Weight
411.04
Precautions
H302, H315, H319, H335
References & Citations
[1]Li Z, et al. Allele-selective lowering of mutant HTT protein by HTT-LC3 linker compounds. Nature. 2019 Nov;575 (7781) :203-209.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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