Bax Antibody [6A7]
Product Specifications
Background
Bax is a 20-22 kDa member of the Bcl-2 family of proteins involved in regulation of programmed cell death, or apoptosis. In murine thymocytes, it is expressed primarily as a cytoplasmic protein. Over-expression of Bax promotes apoptosis by formation of homodimers and through heterodimerization with Bcl-2, an inhibitor of apoptosis. The monoclonal antibody 6A7 reacts with human, mouse and rat Bax but does not bind the soluble cytosolic form of Bax; however, treatment of cells with non-ionic detergents exposes the epitope and allows binding of 6A7 to monomeric forms of Bax but not Bax complexed with either Bcl-2 or Bcl-xL.
NCBI Gene ID
581;12028;24887
Swiss Prot
Q07812
Accession Number
Q07812
Host
Mouse
Reactivity
Human, Mouse, Rat, Monkey, Bovine
Immunogen
Bax peptide (a.a. 12-24) common to mouse, rat, and human
Clonality
Monoclonal
Clone
[6A7]
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle, Obesity
Concentration
0.1 mg/mL
Buffer
Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store vial at 2-8˚ C
Fragment
IgG1
Specificity
Bax
Applications Notes
Bax Antibody [6A7] for use in flow cytometry, immunohistochemistry / immunocytochemistry, electron microscopy, western blotting, immunoprecipitation, and neutralization assays.
Symbol
BAX
NCBI Official Name
BCL2 associated X, apoptosis regulator
NCBI Organism
Homo sapiens
Other Product Names
Apoptosis regulator BAX, BCL2 associated X protein
Tested Applications
Flow
Physical Properties
Liquid
Curated Selection
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