Antagonist G
Antagonist G is a potent vasopressin antagonist. Antagonist G is also a weak antagonist of GRP and Bradykinin. Antagonist G induces AP-1 transcription and sensitizes cells to chemotherapy[1][2].
Product Specifications
CAS Number
115150-59-9
UNSPSC
12352209
Target
Apoptosis; Vasopressin Receptor
Type
Peptides
Related Pathways
Apoptosis; GPCR/G Protein
Applications
Cancer-programmed cell death
Field of Research
Cancer; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/antagonist-g.html
Purity
99.05
Solubility
H2O : 50 mg/mL (ultrasonic)
Smiles
CSCC[C@@H](C(N)=O)NC([C@H](CC(C)C)NC([C@@H](CC1=CNC2=C1C=CC=C2)NC([C@H](CC3=CC=CC=C3)N(C([C@@H](CC4=CNC5=C4C=CC=C5)NC([C@H](CCCNC(N)=N)N)=O)=O)C)=O)=O)=O
Molecular Formula
C49H66N12O6S
Molecular Weight
951.19
References & Citations
[1]P J Woll, et al. A neuropeptide antagonist that inhibits the growth of small cell lung cancer in vitro. Cancer Res. 1990 Jul 1;50 (13) :3968-73.|[2]A C MacKinnon, et al. [Arg6, D-Trp7,9, NmePhe8]-substance P (6–11) (antagonist G) inducesP-1 transcription and sensitizes cells to chemotherapy. Br J Cancer. 2000 Oct; 83 (7) : 941–948.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)
Scientific Category
Peptides
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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