Antagonist G
Antagonist G is a potent vasopressin antagonist. Antagonist G is also a weak antagonist of GRP and Bradykinin. Antagonist G induces AP-1 transcription and sensitizes cells to chemotherapy[1][2].
Product Specifications
CAS Number
115150-59-9
UNSPSC
12352209
Target
Apoptosis; Vasopressin Receptor
Type
Peptides
Related Pathways
Apoptosis; GPCR/G Protein
Applications
Cancer-programmed cell death
Field of Research
Cancer; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/antagonist-g.html
Purity
99.05
Solubility
H2O : 50 mg/mL (ultrasonic)
Smiles
CSCC[C@@H](C(N)=O)NC([C@H](CC(C)C)NC([C@@H](CC1=CNC2=C1C=CC=C2)NC([C@H](CC3=CC=CC=C3)N(C([C@@H](CC4=CNC5=C4C=CC=C5)NC([C@H](CCCNC(N)=N)N)=O)=O)C)=O)=O)=O
Molecular Formula
C49H66N12O6S
Molecular Weight
951.19
References & Citations
[1]P J Woll, et al. A neuropeptide antagonist that inhibits the growth of small cell lung cancer in vitro. Cancer Res. 1990 Jul 1;50 (13) :3968-73.|[2]A C MacKinnon, et al. [Arg6, D-Trp7,9, NmePhe8]-substance P (6–11) (antagonist G) inducesP-1 transcription and sensitizes cells to chemotherapy. Br J Cancer. 2000 Oct; 83 (7) : 941–948.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)
Scientific Category
Peptides
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
YP-W31716-01 48 Tests
Rat α1 plasminogen inhibitor (α1-PI) ELISA Kit
Sign In for Pricing
View Details YP-W31716-02 96 Tests
Rat α1 plasminogen inhibitor (α1-PI) ELISA Kit
Sign In for Pricing
View Details 
K3568508 1.0 µg DNA
Mia2 sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 3)
Sign In for Pricing
View Details