PKN beta Antibody
Product Specifications
Background
PKN3, a protein kinase C-related molecule, mediates malignant cell growth downstream of activated PI3K. PKN3 is required for invasive prostate cell growth as assessed by 3D cell culture assays and in an orthotopic mouse tumor model by inducible expression of short hairpin RNA (shRNA) . PKN3 is regulated by PI3K at both the expression level and the catalytic activity level. Therefore, PKN3 might represent a preferred target for therapeutic intervention in cancers that lack tumor suppressor PTEN function or depend on chronic activation of PI3K.
NCBI Gene ID
29941
Swiss Prot
Q6P5Z2
Accession Number
Q6P5Z2
Host
Rabbit
Reactivity
Human
Immunogen
This PKN beta antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 463-492 amino acids from the C-terminal region of human PKN beta.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=63-297
Calculated Molecular Weight
99 kDa
Fragment
Rabbit Ig
Symbol
PKN3
NCBI Official Name
Serine/threonine-protein kinase N3
NCBI Organism
Homo sapiens
Background Reference 01
Oishi, K., et al., Biochem. Biophys. Res. Commun. 261 (3) :808-814 (1999) .
Other Product Names
Serine/threonine-protein kinase N3, Protein kinase PKN-beta, Protein-kinase C-related kinase 3, PKN3, PKNBETA
Tested Applications
WB, IHC-P
Protein ID
74749130
Physical Properties
Liquid
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