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Xaliproden (free base)

Xaliproden free base is an orally active and selective 5-HT1A receptor agonist. Xaliproden free base shows analgesic effect against acute tonic nociceptive pain and has neuroprotective effects. Xaliproden free base has an acute inhibitory effect on paclitaxel (HY-B0015) -induced mechanical allodynia by inhibiting the excessive response of primary afferent neurons[1].

Product Specifications

CAS Number

[135354-02-8]

Product Name Alternative

SR57746A (free base)

UNSPSC

12352005

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/xaliproden-free-base.html

Solubility

10 mM in DMSO

Smiles

FC(F)(F)C1=CC(C2=CCN(CC2)CCC3=CC=C4C=CC=CC4=C3)=CC=C1

Molecular Formula

C24H22F3N

Molecular Weight

381.43

References & Citations

[1]Andoh T, et al. Effects of xaliproden, a 5-HT₁A agonist, on mechanical allodynia caused by chemotherapeutic agents in mice. Eur J Pharmacol. 2013 Dec 5;721 (1-3) :231-6.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

Phase 3

Isoform

5-HT1 Receptor

Curated Selection

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