LINGO1 Antibody

Product Specifications

Background

LINGO1 is a functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. It is also an important negative regulator of oligodentrocyte differentiation and axonal myelination.

NCBI Gene ID

84894

Swiss Prot

Q96FE5

Accession Number

Q96FE5

Host

Rabbit

Reactivity

Human

Immunogen

This LINGO1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 62-92 amino acids from the N-terminal region of human LINGO1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle, Neuroscience

Purification

This antibody is purified through a protein G column, followed by dialysis against PBS.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Chicken, Monkey, Mouse

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

70 kDa

Fragment

Rabbit Ig

Symbol

LINGO1

NCBI Official Name

Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1

NCBI Organism

Homo sapiens

Background Reference 01

Inoue, H., Proc. Natl. Acad. Sci. U.S.A. 104 (36), 14430-14435 (2007)

Background Reference 02

Satoh, J., Neuropathol. Appl. Neurobiol. 33 (1), 99-107 (2007)

Background Reference 03

Mosyak, L., J. Biol. Chem. 281 (47), 36378-36390 (2006)

Background Reference 04

Mi, S., Nat. Neurosci. (3), 221-228 (2004)

Other Product Names

Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1, Leucine-rich repeat and immunoglobulin domain-containing protein 1, Leucine-rich repeat neuronal protein 1, Leucine-rich repeat neuronal protein 6A, LINGO1, LERN1, LRRN6A