LM10
LM10 is a potent inhibitor of tryptophan 2,3-dioxygenase (TDO) . Tryptophan 2,3-dioxygenase (TDO) is an unrelated hepatic enzyme that also degrades tryptophan along the kynurenine pathway. LM10 has the potential for the research of cancer diseases[1].
Product Specifications
CAS Number
[1316695-35-8]
UNSPSC
12352005
Hazard Statement
H240
Target
Indoleamine 2,3-Dioxygenase (IDO)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/lm10.html
Purity
99.94
Solubility
DMSO : 50 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
FC1=CC2=C(C=C1)C(/C=C/C3=NN=NN3)=CN2
Molecular Formula
C11H8FN5
Molecular Weight
229.22
Precautions
H240
References & Citations
[1]Pilotte L, et al. Reversal of tumoral immune resistance by inhibition of tryptophan 2,3-dioxygenase. Proc Natl Acad Sci U S A. 2012;109 (7) :2497-2502.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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