LM10

LM10 is a potent inhibitor of tryptophan 2,3-dioxygenase (TDO) . Tryptophan 2,3-dioxygenase (TDO) is an unrelated hepatic enzyme that also degrades tryptophan along the kynurenine pathway. LM10 has the potential for the research of cancer diseases[1].

Product Specifications

CAS Number

[1316695-35-8]

UNSPSC

12352005

Hazard Statement

H240

Target

Indoleamine 2,3-Dioxygenase (IDO)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/lm10.html

Purity

99.94

Solubility

DMSO : 50 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

FC1=CC2=C(C=C1)C(/C=C/C3=NN=NN3)=CN2

Molecular Formula

C11H8FN5

Molecular Weight

229.22

Precautions

H240

References & Citations

[1]Pilotte L, et al. Reversal of tumoral immune resistance by inhibition of tryptophan 2,3-dioxygenase. Proc Natl Acad Sci U S A. 2012;109 (7) :2497-2502.