NAE1 Antibody
Product Specifications
Background
APPBP1 binds to the beta-amyloid precursor protein, a cell surface protein with signal-transducing properties thought to play a role in the pathogenesis of Alzheimer's disease. In addition, this protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. APPB1 is required for cell cycle progression through the S/M checkpoint.
NCBI Gene ID
8883
Swiss Prot
Q13564
Accession Number
Q13564
Host
Rabbit
Reactivity
Human
Immunogen
This NAE1 (APPBP1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 430-459 amino acids from the C-terminal region of human NAE1 (APPBP1) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle
Purification
This antibody is purified through a protein G column, followed by dialysis against PBS.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Monkey, Mouse, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
60 kDa
Fragment
Rabbit Ig
Symbol
NAE1
NCBI Official Name
NEDD8-activating enzyme E1 regulatory subunit
NCBI Organism
Homo sapiens
Background Reference 01
Chen, Y., J. Cell Biol. 163 (1), 27-33 (2003)
Background Reference 02
Chen, Y., J. Neurochem. 85 (3), 801-809 (2003)
Background Reference 03
Walden, H., Nature 422 (6929), 330-334 (2003)
Background Reference 04
Chow, N., J. Biol. Chem. 271 (19), 11339-11346 (1996)
Other Product Names
NEDD8-activating enzyme E1 regulatory subunit, Amyloid beta precursor protein-binding protein 1, 59 kDa, APP-BP1, Amyloid protein-binding protein 1, Proto-oncogene protein 1, NAE1, APPBP1
Tested Applications
WB, IHC-P
Protein ID
50400302
Physical Properties
Liquid
Frequently Asked Questions
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