BM-962

BM-962 (Compound 31) is a potent small-molecule inhibitor of Bcl-2 with an IC50 value of 4 nM (Ki=0.8 nM) and Bcl-xL with an IC50 value of 3.9 nM (Ki IC50 values of 9 and 13 nM, respectively. BM-962 is promising for research of cancers[1][2].

Product Specifications

CAS Number

[1391107-57-5]

UNSPSC

12352005

Target

Bcl-2 Family

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/bm-962.html

Purity

99.10

Solubility

DMSO : 200 mg/mL (ultrasonic)

Smiles

OC(C1=C(C)N(C(C)C)C(C2=CC=C(C=C2)Cl)=C1C3=CC(N4CCN(C5=CC=C(C=C5)NS(=O)(C6=CC(S(C(F)(F)F)(=O)=O)=C(C=C6)N[C@@H](CSC7=CC=CC=C7)CCN8CCC(CC8)O)=O)CC4)=CC=C3)=O

Molecular Formula

C53H58ClF3N6O7S3

Molecular Weight

1079.71

References & Citations

[1]Chen J, et al. Structure-based discovery of BM-957 as a potent small-molecule inhibitor of Bcl-2 and Bcl-xL capable of achieving complete tumor regression. J Med Chem. 2012 Oct 11;55 (19) :8502-14.|[2]Wang SM, et al. Bcl-2/Bcl-xL inhibitors and therapeutic methods using the same. US20120189539. 2012 July 26.