BM-962
BM-962 (Compound 31) is a potent small-molecule inhibitor of Bcl-2 with an IC50 value of 4 nM (Ki=0.8 nM) and Bcl-xL with an IC50 value of 3.9 nM (Ki IC50 values of 9 and 13 nM, respectively. BM-962 is promising for research of cancers[1][2].
Product Specifications
CAS Number
1391107-57-5
UNSPSC
12352005
Target
Bcl-2 Family
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bm-962.html
Purity
99.10
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
OC(C1=C(C)N(C(C)C)C(C2=CC=C(C=C2)Cl)=C1C3=CC(N4CCN(C5=CC=C(C=C5)NS(=O)(C6=CC(S(C(F)(F)F)(=O)=O)=C(C=C6)N[C@@H](CSC7=CC=CC=C7)CCN8CCC(CC8)O)=O)CC4)=CC=C3)=O
Molecular Formula
C53H58ClF3N6O7S3
Molecular Weight
1079.71
References & Citations
[1]Chen J, et al. Structure-based discovery of BM-957 as a potent small-molecule inhibitor of Bcl-2 and Bcl-xL capable of achieving complete tumor regression. J Med Chem. 2012 Oct 11;55 (19) :8502-14.|[2]Wang SM, et al. Bcl-2/Bcl-xL inhibitors and therapeutic methods using the same. US20120189539. 2012 July 26.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
