TXNDC5 (NM_022085) Human Recombinant Protein
Product Specifications
Background
This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal endoplasmic reticulum (ER) -signal sequence, three catalytically active thioredoxin domains and a C-terminal ER-retention sequence. Its expression is induced by hypoxia and its role may be to protect hypoxic cells from apoptosis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring upstream BLOC1S5 gene. [provided by RefSeq, Dec 2016]
Overview
Recombinant protein of human thioredoxin domain containing 5 (TXNDC5), transcript variant 2
Synonyms
ERP46, Hcc-2, UNQ364, EndoPDI, MGC3178; thioredoxin domain containing 5
Gene ID
81567
UniProt
Q8NBS9
Accession Number mRNA
NM_022085
Chromosomal Location
6p24.3
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome
Molecular Weight
43.5 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
TXNDC5
Species
Human
Protein ID
NP_071368
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/81567
Uniprot URL
https://www.uniprot.org/uniprot/Q8NBS9
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_022085
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_071368
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