SUN2 (NM_015374) Human Recombinant Protein
Product Specifications
Background
SUN1 (MIM 607723) and SUN2 are inner nuclear membrane (INM) proteins that play a major role in nuclear-cytoplasmic connection by formation of a 'bridge' across the nuclear envelope, known as the LINC complex, via interaction with the conserved luminal KASH domain of nesprins (e.g., SYNE1; MIM 608441) located in the outer nuclear membrane (ONM) . The LINC complex provides a direct connection between the nuclear lamina and the cytoskeleton, which contributes to nuclear positioning and cellular rigidity (summary by Haque et al., 2010 [PubMed 19933576]) .[supplied by OMIM, Nov 2010]
Overview
Recombinant protein of human unc-84 homolog B (C. elegans) (UNC84B)
Synonyms
UNC84B
Gene ID
25777
UniProt
Q9UH99, A0A024R1P7, B4E2A6
Accession Number mRNA
NM_015374
Chromosomal Location
22q13.1
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Transmembrane
Molecular Weight
80.1 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
SUN2
Species
Human
Protein ID
NP_056189
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/25777
Uniprot URL
https://www.uniprot.org/uniprot/Q9UH99
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_015374
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_056189
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