PRAK (MAPKAPK5) Mouse Monoclonal Antibody [Clone ID: LBI5E1]

Product Specifications

Background

The protein encoded by this gene is a tumor suppressor and member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. The encoded protein is found in the nucleus but translocates to the cytoplasm upon phosphorylation and activation. This kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov

Overview

Purified MAPKAPK5 mouse monoclonal antibody, clone LBI5E1

Synonyms

MAPKAP-K5; MK-5; MK5; PRAK

Gene Name

Mitogen-activated protein kinase-activated protein kinase 5

Gene ID

8550

UniProt

Q8IW41

Conjugation

Unconjugated

Related Pathways

MAPK signaling pathway

Field of Research

MAPK signaling pathway

Concentration

1 mg/ml

Dilution

WB 1:2000

Form

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Buffer

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Function

Druggable Genome, Protein Kinase

Storage Conditions

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.