INT-767
INT-767 is a dual farnesoid X receptor (FXR) /TGR5 agonist with mean EC50s of 30 and 630 nM, respectively[1][2].
Product Specifications
CAS Number
1000403-03-1
UNSPSC
12352100
Target
Autophagy; FXR; G protein-coupled Bile Acid Receptor 1
Type
Reference compound
Related Pathways
Autophagy; GPCR/G Protein; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/INT-767.html
Purity
99.81
Solubility
DMSO : ≥ 100 mg/mL|H2O : 100 mg/mL (ultrasonic)
Smiles
C[C@H](CCOS(=O)(O[Na])=O)[C@@]1([H])CC[C@@]2([H])[C@]3([H])[C@H](O)[C@H](CC)[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C
Molecular Formula
C25H43NaO6S
Molecular Weight
494.66
References & Citations
[1]Baghdasaryan A, et al. Dual farnesoid X receptor/TGR5 agonist INT-767 reduces liver injury in the Mdr2-/- (Abcb4-/-) mousecholangiopathy model by promoting biliary HCO3- output. Hepatology. 2011 Oct;54 (4) :1303-1312.|[2]Rizzo G, et al. Functional characterization of the semisynthetic bile acid derivative INT-767, a dual farnesoid X receptor andTGR5 agonist. Mol Pharmacol. 2010 Oct;78 (4) :617-630.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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