INT-767

INT-767 is a dual farnesoid X receptor (FXR) /TGR5 agonist with mean EC50s of 30 and 630 nM, respectively[1][2].

Product Specifications

CAS Number

[1000403-03-1]

UNSPSC

12352100

Target

Autophagy; FXR; G protein-coupled Bile Acid Receptor 1

Type

Reference compound

Related Pathways

Autophagy; GPCR/G Protein; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/INT-767.html

Purity

99.81

Solubility

DMSO : ≥ 100 mg/mL|H2O : 100 mg/mL (ultrasonic)

Smiles

C[C@H](CCOS(=O)(O[Na])=O)[C@@]1([H])CC[C@@]2([H])[C@]3([H])[C@H](O)[C@H](CC)[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C

Molecular Formula

C25H43NaO6S

Molecular Weight

494.66

References & Citations

[1]Baghdasaryan A, et al. Dual farnesoid X receptor/TGR5 agonist INT-767 reduces liver injury in the Mdr2-/- (Abcb4-/-) mousecholangiopathy model by promoting biliary HCO3- output. Hepatology. 2011 Oct;54 (4) :1303-1312.|[2]Rizzo G, et al. Functional characterization of the semisynthetic bile acid derivative INT-767, a dual farnesoid X receptor andTGR5 agonist. Mol Pharmacol. 2010 Oct;78 (4) :617-630.