Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

INT-767

Product Specifications

UNSPSC Description

INT-767 is a dual farnesoid X receptor (FXR)/TGR5 agonist with mean EC50s of 30 and 630 nM, respectively[1][2].

Target Antigen

Autophagy; FXR; G protein-coupled Bile Acid Receptor 1

Type

Reference compound

Related Pathways

Autophagy;GPCR/G Protein;Metabolic Enzyme/Protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/INT-767.html

Purity

99.81

Solubility

DMSO : ≥ 100 mg/mL|H2O : 100 mg/mL (ultrasonic)

Smiles

C[C@H](CCOS(=O)(O[Na])=O)[C@@]1([H])CC[C@@]2([H])[C@]3([H])[C@H](O)[C@H](CC)[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C

Molecular Weight

494.66

References & Citations

[1]Baghdasaryan A, et al. Dual farnesoid X receptor/TGR5 agonist INT-767 reduces liver injury in the Mdr2-/- (Abcb4-/-) mousecholangiopathy model by promoting biliary HCO3- output. Hepatology. 2011 Oct;54(4):1303-1312.|[2]Rizzo G, et al. Functional characterization of the semisynthetic bile acid derivative INT-767, a dual farnesoid X receptor andTGR5 agonist. Mol Pharmacol. 2010 Oct;78(4):617-630.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-12434/INT-767-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-12434/INT-767-SDS-MedChemExpress.pdf

Clinical Information

No Development Reported

CAS Number

1000403-03-1

Available Sizes

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

Heterochromatin Protein 1, gamma (HP1g, M32) (AP)
MBS6241886-01 0.1 mL

Heterochromatin Protein 1, gamma (HP1g, M32) (AP)

Ask
View Details
Heterochromatin Protein 1, gamma (HP1g, M32) (AP)
MBS6241886-02 5x 0.1 mL

Heterochromatin Protein 1, gamma (HP1g, M32) (AP)

Ask
View Details
Zfp444 Mouse shRNA Plasmid (Locus ID 72667)
TR512025 1 Kit

Zfp444 Mouse shRNA Plasmid (Locus ID 72667)

Ask
View Details
REEP2 Polyclonal Antibody, HRP Conjugated
A60573-100 100 µL

REEP2 Polyclonal Antibody, HRP Conjugated

Ask
View Details
ZMYND17 (MSS51) (NM_001024593) Human Tagged Lenti ORF Clone
RC222812L1 10 µg

ZMYND17 (MSS51) (NM_001024593) Human Tagged Lenti ORF Clone

Ask
View Details
Recombinant Ginkgo biloba Cytochrome c
MBS1023373-01 0.02 mg (E-Coli)

Recombinant Ginkgo biloba Cytochrome c

Ask
View Details