DERL1 Antibody - C-terminal region : Biotin (ARP73820_P050-Biotin)

The protein encoded by this gene is a member of the derlin family. Members of this family participate in the ER-associated degradation response and retrotranslocate misfolded or unfolded proteins from the ER lumen to the cytosol for proteasomal degradation. This protein recognizes substrate in the ER and works in a complex to retrotranslocate it across the ER membrane into the cytosol. This protein may select cystic fibrosis transmembrane conductance regulator protein (CFTR) for degradation as well as unfolded proteins in Alzheimer's disease. Alternative splicing results in multiple transcript variants that encode different protein isoforms.

HM13; TCF25; XBP1; EGFR; USP19; ZFAND2B; Vcp; PTGS2; CAV1; SYVN1; DERL2; SHH; SEL1L; SERPINA1; FAF2; ALB; APP; DERL1; EDEM1; RNF5; RHO; NGLY1; BCAP31; CFTR; UBXN6; TRAM1; APOB; CLN6; UBXN4; ERN1; ASGR2; UBE2J1; ERLIN2; UBC; HLA-A; CACNA1C; YOD1; VIMP; KPN

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.