Anti-Syntaxin 1a/STX1A Antibody Picoband®

Syntaxin-1A is a member of the syntaxin superfamily. Syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. Syntaxins possess a single C-terminal transmembrane domain, a SNARE [Soluble NSF (N-ethylmaleimide-sensitive fusion protein) -Attachment protein REceptor] domain (known as H3), and an N-terminal regulatory domain (Habc) . Syntaxins bind synaptotagminin a calcium-dependent fashion and interact with voltage dependent calcium and potassium channels via the C-terminal H3 domain. Syntaxin-1A is a key protein in ion channel regulation and synaptic exocytosis.

A synthetic peptide corresponding to a sequence at the N-terminus of human Syntaxin 1a, different from the related mouse and rat sequences by one amino acid.

Isoform 1 is highly expressed in embryonic spinal chord and ganglia and in adult cerebellum and cerebral cortex. Isoform 2 is expressed in heart, liver, fat, skeletal muscle, kidney and brain. .

Plays a role in hormone and neurotransmitter exocytosis (By similarity) . Potentially involved in docking of synaptic vesicles at presynaptic active zones. May mediate Ca (2+) - regulation of exocytosis acrosomal reaction in sperm. .

1. Entrez Gene: STX1A syntaxin 1A (brain) . 2. Bennett MK, García-Arrarás JE, Elferink LA, Peterson K, Fleming AM, Hazuka CD, Scheller RH (September 1993) . The syntaxin family of vesicular transport receptors.Cell 74 (5) : 863–73.

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Single-pass type IV membrane protein . Cell junction, synapse, synaptosome . Cell membrane . Colocalizes with KCNB1 at the cell membrane. .