Candidalysin

Candidalysin is a cytolytic peptide toxin secreted by the fungus Candida albicans. Candidalysin drives epithelial immune responses by activating the EGFR-MAPK signaling pathway, inducing MMP expression and calcium influx, and regulating the c-Fos transcription factor and MKP1 via p38 MAPK and ERK1/2 respectively. Candidalysin is essential for mucosal and systemic infections, activating NLRP3 to promote inflammatory responses, neutrophil recruitment, and Th17 immunity. Candidalysin activates LDH causing membrane damage and exhibiting cytotoxicity[1][2][3][4]

Product Specifications

CAS Number

[1906866-53-2]

UNSPSC

12352209

Target

Calcium Channel; EGFR; ERK; MMP; NOD-like Receptor (NLR) ; p38 MAPK

Type

Peptides

Related Pathways

Immunology/Inflammation; JAK/STAT Signaling; MAPK/ERK Pathway; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/candidalysin.html

Purity

99.38

Solubility

DMSO : 25 mg/mL (ultrasonic) |H2O : 25 mg/mL (ultrasonic)

Smiles

OC[C@H](N)C(N[C@@H]([C@@H](C)CC)C(N[C@@H]([C@@H](C)CC)C(NCC(N[C@@H]([C@@H](C)CC)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCSC)C(NCC(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC(C)C)C(NCC(N[C@@H](CC(N)=O)C(N[C@@H]([C@@H](C)CC)C(N1[C@@H](CCC1)C(N[C@@H](CCC(N)=O)C(N[C@@H](C(C)C)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCC(N)=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCSC)C(N[C@@H](CO)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](C(C)C)C(N[C@@H](CCCCN)C(N[C@@H](C)C(N[C@H](C(N[C@@H](CCCCN)C(NCC(N[C@@H](CC(N)=O)C(N[C@H](C(O)=O)CCCCN)=O)=O)=O)=O)CC2=CC=CC=C2)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O

Molecular Formula

C153H266N38O38S2

Molecular Weight

3310.11

References & Citations

[1]Ho J, et al. Candidalysin activates innate epithelial immune responses via epidermal growth factor receptor. Nat Commun. 2019 May 24;10 (1) :2297.|[2]Richardson JP, et al. Candidalysin Drives Epithelial Signaling, Neutrophil Recruitment, and Immunopathology at the Vaginal Mucosa. Infect Immun. 2018 Jan 22;86 (2) :e00645-17.|[3]Rogiers O, et al. Candidalysin Crucially Contributes to Nlrp3 Inflammasome Activation by Candida albicans Hyphae. mBio. 2019 Jan 8;10 (1) :e02221-18.|[4]Naglik JR, et al. Candidalysin: discovery and function in Candida albicans infections. Curr Opin Microbiol. 2019 Dec;52:100-109.