Taltobulin intermediate-3

Taltobulin intermediate-3 is an intermediate in the synthesis of Taltobulin (HY-15584) . Taltobulin is a common toxin component in ADC preparation (ADC Cytotoxin), and it is also a powerful tubulin (Microtubule/Tubulin) inhibitor. Taltobulin disrupts tubulin polymerization, induces mitotic arrest, and induces apoptosis[1].

Product Specifications

CAS Number

[610786-69-1]

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/taltobulin-intermediate-3.html

Purity

99.88

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC(C)[C@@H](/C=C(C)/C(OCC)=O)NC.Cl

Molecular Formula

C11H22ClNO2

Molecular Weight

235.75

Precautions

H302, H315, H319, H335

References & Citations

[1]Loganzo F, et al. HTI-286, a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo. Cancer Res. 2003 Apr 15;63 (8) :1838-45.