FBPase-IN-1

FBPase-IN-1 is a potent FBPase (Fructose-1,6-bisphosphatase) inhibitor for Type 2 diabetes (T2D) study with an IC50 of 0.22 μM. FBPase-IN-1 can reduce blood glucose levels and ameliorate glucose tolerance. FBPase-IN-1 modifies the C128 site, regulates the N125-S124-S123 allosteric pathway of FBPase and affects the catalytic activity of FBPase[1].

Product Specifications

CAS Number

[20362-54-3]

UNSPSC

12352005

Target

FBPase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/fbpase-in-1.html

Purity

98.30

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

C1(SSC2=NC=CS2)=NC=CS1

Molecular Formula

C6H4N2S4

Molecular Weight

232.37

References & Citations

[1]Xu YX, Huang YY, Song RR, et al. Development of disulfide-derived fructose-1,6-bisphosphatase (FBPase) covalent inhibitors for the treatment of type 2 diabetes. Eur J Med Chem. 2020; 203: 112500.