FBPase-IN-1
Product Specifications
UNSPSC Description
FBPase-IN-1 is a potent FBPase (Fructose-1,6-bisphosphatase) inhibitor for Type 2 diabetes (T2D) study with an IC50 of 0.22 μM. FBPase-IN-1 can reduce blood glucose levels and ameliorate glucose tolerance. FBPase-IN-1 modifies the C128 site, regulates the N125-S124-S123 allosteric pathway of FBPase and affects the catalytic activity of FBPase[1].
Target Antigen
FBPase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/fbpase-in-1.html
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
C1(SSC2=NC=CS2)=NC=CS1
Molecular Weight
232.37
References & Citations
[1]Xu YX, Huang YY, Song RR, et al. Development of disulfide-derived fructose-1,6-bisphosphatase (FBPase) covalent inhibitors for the treatment of type 2 diabetes. Eur J Med Chem. 2020; 203: 112500.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-146725/FBPase-IN-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-146725/FBPase-IN-1-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
20362-54-3
Available Sizes
Curated Selection
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