FBPase-IN-3

FBPase-IN-3 (compound 45) is a FBPase (fructose-1,6-bisphosphatase) inhibitor with an IC50 of 2.08 μM. FBPase-IN-3 exhibits potent inhibitory activity of gluconeogenesis[1].

Product Specifications

UNSPSC

12352005

Target

FBPase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/fbpase-in-3.html

Smiles

O=C(NS(=O)(C1=CC=C(OC)C=C1)=O)C2=CC(Cl)=CC(C3=NC4=CC=CC=C4N3)=C2

Molecular Formula

C21H16ClN3O4S

Molecular Weight

441.89

References & Citations

[1]Huahao Wang, et al. Discovery of novel fructose-1,6-bisphosphatase inhibitors bearing benzimidazole scaffold using a dual-ligand molecular docking model. Eur J Med Chem. 2024 Sep 19:279:116888.