Azido-PEG2-VHL

Azido-PEG2-VHL is a multikinase degrader which can be used in the synthesis of PROTACs[1]. Azido-PEG2-VHL is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Product Specifications

CAS Number

[2597167-22-9]

UNSPSC

12352005

Target

E3 Ligase Ligand-Linker Conjugates

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/azido-peg2-vhl.html

Solubility

10 mM in DMSO

Smiles

[N-]=[N+]=NCCOCCOCCC(N[C@@H](C(C)(C)C)C(N1[C@@H](C[C@H](C1)O)C(NCC2=CC=C(C3=C(N=CS3)C)C=C2)=O)=O)=O

Molecular Formula

C29H41N7O6S

Molecular Weight

615.74

References & Citations

[1]STATSYUK A, et, al. Multikinase degraders. WO2021021797A1.|[2]Chung CW, et, al. Structural Insights into PROTAC-Mediated Degradation of Bcl-xL. ACS Chem Biol. 2020 Sep 18;15 (9) :2316-2323.