BAY 11-7082
BAY 11-7082 (also known as BAY 11-7821) is a cell-permeable small molecule that potently inhibits the deubiquitinases USP7 and USP21, and also suppresses NF-κB activation by blocking TNFα-induced IκBα phosphorylation. This dual activity makes it a valuable research tool for studying inflammatory signaling, immune regulation, and cancer pathways in both cellular and animal models.
Product Specifications
CAS Number
19542-67-7
Product Name Alternative
Ubiquitin, T-cell, phosphorylation, adhesion, Apoptosis, Autophagy, BAY 117082, BAY 11-7082, BAY 11-7821, BAY 11 7082, B-cell, cytokine, Deubiquitinase, DUBs, I kappa B kinase, leukaemic, IKK, IkB, IkB/IKK, E2-conjugating enzymes, Inhibitor, inhibit, IκBα phosphorylation, IκB, IκB kinase, inflammasome, lymphoma
Field of Research
Cell Biology, Neuroscience
Purity
>98%
Bioactivity
IKK inhibitor
Form
Powder
Solubility
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 15 mg/ml) .
Smiles
Cc1ccc (cc1) S (=O) (=O) \C=C\C#N
Molecular Formula
C10H9NO2S
Molecular Weight
207.3
References & Citations
J Guo, X Ma, L Wu, W Zhao, Y Zhang, C Hao, Y Yang, Z Yin, T Xu, Y Zhang, Y Guo, X Cao Inhibition of Nuclear factor kappa B ameliorates bone destruction and osteoclastogenesis in collagen-induced arthritis mice African Health Sciences, (2025)
Pubmed id
41640567
Storage Conditions
RT
Notes
For research use only.
Other Product Names
(E) -3- (4-Methylphenylsulfonyl) -2-propenenitrile
Available Sizes
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