HSMG-1 inhibitor 11j
HSMG-1 inhibitor 11j is a highly potent and selective pyrimidine-based small molecule targeting hSMG-1 kinase (IC50 = 0.11 nM) . It demonstrates significant selectivity over related kinases like mTOR and PI3K and is utilized in cancer research for investigating DNA damage response pathways in cellular models.
Product Specifications
CAS Number
1402452-15-6
Product Name Alternative
MTOR, hSMG 1 inhibitor 11j, hSMG1 inhibitor 11j, hSMG-1 inhibitor 11j, PI3Kα/PI3Kγ
Field of Research
Cell Biology, Pharmacology & Drug Discovery, Signal Transduction, Stem Cell & Developmental Biology
Purity
99.22% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (8.83 mM) ; DMSO:70 mg/mL (123.66 mM)
Smiles
CCN (CC) S (=O) (=O) c1cc (Nc2nccc (n2) -c2ccnc (c2) -c2ccc (NC (=O) NC) cc2) ccc1Cl
Molecular Formula
C27H28ClN7O3S
Molecular Weight
566.07
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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