GSK2578215A
GSK2578215A is a highly potent, selective, BBB-permeable LRRK2 inhibitor with IC50 of 10.9 and 9.9 nM for wild-type LRRK2 and the G2019S mutant, respectively; shows 8-fold reduced potentcy against A2016T mutant LRRK2 (IC50=81 nM) ; inhibits Ser910 and Ser935 phosphorylation in both wild-type LRRK2 and LRRK2 G2019S stably transfected into HEK293 cells at 0.1-0.3 uM, also induces dephosphorylation of Ser910 and 935 at 1-3 μM in the inhibitor-resistant LRRK2[A2016T+ G2019S] and LRRK2 [A2016T] mutants; induces protective autophagy in SH-SY5Y cells.
Product Specifications
CAS Number
1285515-21-0
Product Name Alternative
GSK-2578215A
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
O=C (NC1=CC=CN=C1) C2=CC (C3=CC (F) =NC=C3) =CC=C2OCC4=CC=CC=C4
Molecular Formula
C24H18FN3O2
Molecular Weight
399.417
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Benzamide, 5- (2-fluoro-4-pyridinyl) -2- (phenylmethoxy) -N-3-pyridinyl-
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