PRGL493
Product Specifications
CAS Number
2479378-45-3
Target
Ferroptosis, Others
Related Pathways
Others, Apoptosis
Purity
0.9911
Bioactivity
PRGL493 is an inhibitor of long-chain acyl-CoA synthetase 4 (ACSL4) .1It inhibits formation of arachidonoyl-CoA (AA-CoA) from arachidonic acid in, as well as the proliferation and migration of, PC3 and MDA-MB-231 cancer cells when used at a concentration of 50 μM. PRGL493 (5 μM) reduces production of progesterone induced by 8-Br-cyclic AMP (8-Br-cAMP) in MA-10 Leydig tumor cells. It inhibits tumor growth in a PC3 mouse xenograft model when administered at a dose of 0.25 mg/kg.
Smiles
CC(=O)NC1=NC(N2C(Nc3ccccc23)=N1)c1cn(nc1-c1ccc(C)o1)-c1ccccc1
Molecular Formula
C25H21N7O2
Molecular Weight
451.48
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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