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PRGL493

Product Specifications

CAS Number

2479378-45-3

Target

Ferroptosis, Others

Related Pathways

Others, Apoptosis

Purity

0.9911

Bioactivity

PRGL493 is an inhibitor of long-chain acyl-CoA synthetase 4 (ACSL4) .1It inhibits formation of arachidonoyl-CoA (AA-CoA) from arachidonic acid in, as well as the proliferation and migration of, PC3 and MDA-MB-231 cancer cells when used at a concentration of 50 μM. PRGL493 (5 μM) reduces production of progesterone induced by 8-Br-cyclic AMP (8-Br-cAMP) in MA-10 Leydig tumor cells. It inhibits tumor growth in a PC3 mouse xenograft model when administered at a dose of 0.25 mg/kg.

Smiles

CC(=O)NC1=NC(N2C(Nc3ccccc23)=N1)c1cn(nc1-c1ccc(C)o1)-c1ccccc1

Molecular Formula

C25H21N7O2

Molecular Weight

451.48

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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